Invasive pulmonary aspergilliosis (IPA) is
the most severe form of the disease, when dissemination of the process into
other organs (CNS, parenchymatous organs of abdominal cavity) is possible. Often
the first symptom of invasive mycotic infection is a fever, refractory to
broad-spectrum antibiotics. Absence of a result at treatment with antibacterial
preparations at clinical picture of acute pneumonia in patients with expressed
immune suppression must be regarded as a possibility of IPA development. When
such clinical manifestations are registered diagnostic maneuvers must be
fulfilled. Speed and intensity of IPA manifestations depend on degree of immune
suppression. IPA signs reveal themselves distinctly after granulocytopaenia,
Sometimes IPA diagnosis may be made basing on results of a biopsy only, but a
risk of haemorrhagic complications in patients with hemoblastoses may be one of
barriers for biopsy.
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